Ontology highlight
ABSTRACT:
SUBMITTER: Joslin J
PROVIDER: S-EPMC6055113 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Joslin John J Gilligan James J Anderson Paul P Garcia Catherine C Sharif Orzala O Hampton Janice J Cohen Steven S King Miranda M Zhou Bin B Jiang Shumei S Trussell Christopher C Dunn Robert R Fathman John W JW Snead Jennifer L JL Boitano Anthony E AE Nguyen Tommy T Conner Michael M Cooke Mike M Harris Jennifer J Ainscow Ed E Zhou Yingyao Y Shaw Chris C Sipes Dan D Mainquist James J Lesley Scott S
SLAS discovery : advancing life sciences R & D 20180529 7
The goal of high-throughput screening is to enable screening of compound libraries in an automated manner to identify quality starting points for optimization. This often involves screening a large diversity of compounds in an assay that preserves a connection to the disease pathology. Phenotypic screening is a powerful tool for drug identification, in that assays can be run without prior understanding of the target and with primary cells that closely mimic the therapeutic setting. Advanced auto ...[more]