Rapid Aqueous Late-Stage Radiolabelling of [GaF3 (BnMe2 -tacn)] by 18 F/19 F Isotopic Exchange: Towards New PET Imaging Probes.
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ABSTRACT:
SUBMITTER: Monzittu FM
PROVIDER: S-EPMC6055623 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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Rapid Aqueous Late-Stage Radiolabelling of [GaF<sub>3</sub> (BnMe<sub>2</sub> -tacn)] by <sup>18</sup> F/<sup>19</sup> F Isotopic Exchange: Towards New PET Imaging Probes.
Monzittu Francesco M FM Khan Imtiaz I Levason William W Luthra Sajinder K SK McRobbie Graeme G Reid Gillian G
Angewandte Chemie (International ed. in English) 20180426 22
A simple and rapid method for <sup>18</sup> F radiolabelling of [GaF<sub>3</sub> (BnMe<sub>2</sub> -tacn)] by <sup>18</sup> F/<sup>19</sup> F isotopic exchange is described. The use of MeCN/H<sub>2</sub> O or EtOH/H<sub>2</sub> O (75:25) and aqueous [<sup>18</sup> F]F<sup>-</sup> (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % <sup>18</sup> F incorporation at a concentration of 268 nm, and 37±5 % <sup>18</sup> F incorporation at even lower concentration (27 nm), without the need for a L ...[more]
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