A more randomly organized grey matter network is associated with deteriorating language and global cognition in individuals with subjective cognitive decline.

ABSTRACT: OBJECTIVES:Grey matter network disruptions in Alzheimer's disease (AD) are associated with worse cognitive impairment cross-sectionally. Our aim was to investigate whether indications of a more random network organization are associated with longitudinal decline in specific cognitive functions in individuals with subjective cognitive decline (SCD). EXPERIMENTAL DESIGN:We included 231 individuals with SCD who had annually repeated neuropsychological assessment (3?±?1 years; n?=?646 neuropsychological investigations) available from the Amsterdam Dementia Cohort (54% male, age: 63?±?9, MMSE: 28?±?2). Single-subject grey matter networks were extracted from baseline 3D-T1 MRI scans and we computed basic network (size, degree, connectivity density) and higher-order (path length, clustering, betweenness centrality, normalized path length [lambda] and normalized clustering [gamma]) parameters at whole brain and/or regional levels. We tested associations of network parameters with baseline and annual cognition (memory, attention, executive functioning, language composite scores, and global cognition [all domains with MMSE]) using linear mixed models, adjusted for age, sex, education, scanner and total gray matter volume. PRINCIPAL OBSERVATIONS:Lower network size was associated with steeper decline in language (??±?SE?=?0.12?±?0.05, p?

SUBMITTER: Verfaillie SCJ 

PROVIDER: S-EPMC6055627 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature