Ontology highlight
ABSTRACT:
SUBMITTER: Lockhart Z
PROVIDER: S-EPMC6055681 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lockhart Zachariah Z Knipe Peter C PC
Angewandte Chemie (International ed. in English) 20180612 28
Foldamers are an important class of abiotic macromolecules, with potential therapeutic applications in the disruption of protein-protein interactions. The majority adopt a single conformational motif such as a helix. A class of foldamer is now introduced where the choice of heterocycle within each monomer, coupled with a strong conformation-determining dipole repulsion effect, allows both helical and extended conformations to be selected. Combining these monomers into hetero-oligomers enables hi ...[more]