Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Beltran J
PROVIDER: S-EPMC6055991 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Rodriguez-Beltran Jeronimo J Hernandez-Beltran J Carlos R JCR DelaFuente Javier J Escudero Jose A JA Fuentes-Hernandez Ayari A MacLean R Craig RC Peña-Miller Rafael R San Millan Alvaro A
Nature ecology & evolution 20180409 5
Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which provide functional redundancy. Bacterial multicopy plasmids provide a paradigmatic ex ...[more]