Dataset Information

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

ABSTRACT: INTRODUCTION:Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland. METHODS:The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped. RESULTS:The mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 ?g/l vs. 856.6±13.05 ?g/l, p<0.01). When compared in quartiles a significant association of higher zinc concentration with the incidence of prostate cancer was observed. The highest OR (OR = 4.41, 95%CI 2.07-9.37, p<0.01) was observed in 3rd quartile (>853.0-973.9 ?g/l). Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19-4.82, p = 0.015). CONCLUSION:Our results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.

SUBMITTER: Bialkowska K

PROVIDER: S-EPMC6056054 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

Białkowska Katarzyna K Marciniak Wojciech W Muszyńska Magdalena M Baszuk Piotr P Gupta Satish S Jaworska-Bieniek Katarzyna K Sukiennicki Grzegorz G Durda Katarzyna K Gromowski Tomasz T Prajzendanc Karolina K Cybulski Cezary C Huzarski Tomasz T Gronwald Jacek J Dębniak Tadeusz T Scott Rodney J RJ Lubiński Jan J Jakubowska Anna A

PloS one 20180723 7

<h4>Introduction</h4>Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.<h4>Methods</h4>The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measur ...[more]

PMID: 30036379

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Project description:PurposeEpilepsy is a disease of neurological character. Approximately one third of epileptic patients demonstrate a drug-resistant phenotype, which is associated with the development of drug-resistant epilepsy. The multidrug resistance protein 1 and glycoprotein P, encoded by MDR1, play a significant role in the transmembrane transport of anti-epileptic agents. Single nucleotide polymorphism C3435T (rs1045642) within MDR1 gene may be associated with an increased expression of P-gp which affects the levels of antiepileptic drugs in plasma. The presented studies analysed the association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children.MethodsC3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz. Genotype and allele distributions were evaluated and their compatibility with the Hardy-Weinberg distribution was assessed by means of the χ(2) test. Genotype and allele evaluation, regarding their relationship with a given feature, was supported by an analysis of odds ratio and 95 % confidence interval, calculated according to the logistic regression model.ResultsAn association was observed between the incidence rate of DRE and the presence of C allele in C3435T polymorphism of MDR1 gene, which may enhance the risk of the disease. The T allele may then play a protective role. No differences were found in the studied groups, regarding either genotype or allele distribution in reference to patient's gender or concomitant diseases.ConclusionFollowing the obtained results, C3435T polymorphism of MDR1 gene may be connected with the incidence of drug-resistant epilepsy in the population of Polish children. ISRCTN ISRCTN73824458. Registered 28th September 2014.

Dataset Information

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

Publications

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

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