Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

ABSTRACT:

Introduction

Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.

Methods

The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped.

Results

The mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 μg/l vs. 856.6±13.05 μg/l, p<0.01). When compared in quartiles a significant assoc

SUBMITTER: Bialkowska K 

PROVIDER: S-EPMC6056054 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature