Ontology highlight
ABSTRACT:
SUBMITTER: Eisenhaber B
PROVIDER: S-EPMC6056205 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Eisenhaber Birgit B Sinha Swati S Wong Wing-Cheong WC Eisenhaber Frank F
Cell cycle (Georgetown, Tex.) 20180515 7
Distant homology relationships among proteins with many transmembrane regions (TMs) are difficult to detect as they are clouded by the TMs' hydrophobic compositional bias and mutational divergence in connecting loops. In the case of several GPI lipid anchor biosynthesis pathway components, the hidden evolutionary signal can be revealed with dissectHMMER, a sequence similarity search tool focusing on fold-critical, high complexity sequence segments. We find that a sequence module with 10 TMs in P ...[more]