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The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas.

ABSTRACT: Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR-194, and miR-215 were upregulated in ovarian carcinomas of the mucinous subtype, but downregulated in other types of carcinoma and in sex cord-stromal tumors. The expression of the said miRNAs was 6-fold higher in mucinous tumors compared to the other histotypes making them candidates for a possible role as diagnostic biomarkers.

SUBMITTER: Agostini A

PROVIDER: S-EPMC6056508 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas.

Agostini Antonio A Brunetti Marta M Davidson Ben B Tropé Claes G CG Eriksson Ane Gerda Z AGZ Heim Sverre S Panagopoulos Ioannis I Micci Francesca F

Scientific reports 20180723 1

Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR ...[more]

PMID: 30038317

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