Ontology highlight
ABSTRACT:
SUBMITTER: Almeida-Souza L
PROVIDER: S-EPMC6057269 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Almeida-Souza Leonardo L Frank Rene A W RAW García-Nafría Javier J Colussi Adeline A Gunawardana Nushan N Johnson Christopher M CM Yu Minmin M Howard Gillian G Andrews Byron B Vallis Yvonne Y McMahon Harvey T HT
Cell 20180607 2
Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that the protein FCHSD2 is a major activator of actin polymerization during CME. FCHSD2 deletion leads to decreased ligand uptake caused by slowed pit maturation. FCHSD2 is recruited to endocytic pits ...[more]