Ontology highlight
ABSTRACT:
SUBMITTER: Fornes O
PROVIDER: S-EPMC6057437 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Fornes Oriol O Gheorghe Marius M Richmond Phillip A PA Arenillas David J DJ Wasserman Wyeth W WW Mathelier Anthony A
Scientific data 20180724
Interpreting the functional impact of noncoding variants is an ongoing challenge in the field of genome analysis. With most noncoding variants associated with complex traits and disease residing in regulatory regions, altered transcription factor (TF) binding has been proposed as a mechanism of action. It is therefore imperative to develop methods that predict the impact of noncoding variants at TF binding sites (TFBSs). Here, we describe the update of our MANTA database that stores: 1) TFBS pre ...[more]