Processing of protein ADP-ribosylation by Nudix hydrolases.
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ABSTRACT:
SUBMITTER: Palazzo L
PROVIDER: S-EPMC6057610 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Processing of protein ADP-ribosylation by Nudix hydrolases.
Palazzo Luca L Thomas Benjamin B Jemth Ann-Sofie AS Colby Thomas T Leidecker Orsolya O Feijs Karla L H KL Zaja Roko R Loseva Olga O Puigvert Jordi Carreras JC Matic Ivan I Helleday Thomas T Ahel Ivan I
The Biochemical journal 20150601 2
ADP-ribosylation is a post-translational modification (PTM) of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response and apoptosis. Several cellular enzymes, such as macrodomain containing proteins PARG [poly(ADP-ribose) glycohydrolase] and TARG1 [terminal ADP-ribose (ADPr) protein glycohydrolase], reverse protein ADP-ribosylation. In the present study, we show that human Nudi ...[more]
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