Ontology highlight
ABSTRACT:
SUBMITTER: Klein K
PROVIDER: S-EPMC6057939 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Klein Kerstin K Kato Masaru M Frank-Bertoncelj Mojca M Kolling Christoph C Ciurea Adrian A Gay Steffen S Ospelt Caroline C
Scientific reports 20180724 1
Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic potential of BRD1 inhibition in joint-resident cells in RA, synovial fibroblasts (SF) and macrophages. The proliferation of SF was decreased upon BRD1 silencing, accompanied by the d ...[more]