Outcomes and prognostic factors for surgically treated patients with breast cancer spine metastases.

ABSTRACT:

Purpose

The aim of this study is to provide some useful insights into the treatments, outcomes, and prognostic factors of patients with breast cancer spine metastases (BCSM).

Methods

We report a retrospective case series analyzing 87 patients with BCSM who underwent surgical interventions. Independent prognostic factors for SMFS and OS were extracted using univariate and multivariate analyses, the Kaplan-Meier method and the Cox proportional hazards model.

Results

The mean time between primary diagnoses and spinal metastases was 46.8 (median 41, range 0-147 months) months. The analysis showed that lymph node metastasis (p?=?0.043, HR 10.498, 95%CI 1.074-102.588) and estrogen receptor (ER) status (p?=?0.004, HR 0.368, 95%CI 0.189-0.721) can significantly affect SMFS. Furthermore, visceral metastasis (p?=?0.042, HR 2.383, 95%CI 1.032-5.501), multiple metastases (p?=?0.035, HR 2.538, 95%CI 1.066-6.048) and post-op chemotherapy (p?=?0.003, HR 0.312, 95%CI 0.144-0.675) have significant effects on OS. Lastly, patients identified as Luminal A subtype have longer OS.

Conclusions

Lymph node metastases and ER status are independent risk factors in predicting BCSM. Moreover, visceral metastasis, multiple metastases of the spine and post-op chemotherapy are independent prognostic factors. Luminal subtypes have higher rate, but late onset of spine metastases and prolonged survival.

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6058005 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature