Ontology highlight
ABSTRACT:
SUBMITTER: Vomero M
PROVIDER: S-EPMC6058034 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Vomero Marta M Barbati Cristiana C Colasanti Tania T Perricone Carlo C Novelli Lucia L Ceccarelli Fulvia F Spinelli Francesca Romana FR Di Franco Manuela M Conti Fabrizio F Valesini Guido G Alessandri Cristiano C
Frontiers in immunology 20180718
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apo ...[more]