Ontology highlight
ABSTRACT:
SUBMITTER: Ou X
PROVIDER: S-EPMC6058041 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ou Xumin X Wang Mingshu M Mao Sai S Cao Jingyu J Cheng Anchun A Zhu Dekang D Chen Shun S Jia Renyong R Liu Mafeng M Yang Qiao Q Wu Ying Y Zhao Xinxin X Zhang Shaqiu S Liu Yunya Y Yu Yanling Y Zhang Ling L Chen Xiaoyue X Peppelenbosch Maikel P MP Pan Qiuwei Q
Frontiers in cellular and infection microbiology 20180718
Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain). This study aims to understand the mechanisms that drive a virulent strain to an attenuated virus. Here, we systematically compared five DHAV-1 chicken embryo attenuated strains and 68 virulent strains. Phylogenetic analysis indicated that duck virulent strains isolated from differ ...[more]