Ontology highlight
ABSTRACT:
SUBMITTER: Farivar S
PROVIDER: S-EPMC6058186 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Iranian biomedical journal 20180527 5
The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors of gene regulation. In SLE, global and gene-specific DNA methylation changes have been demonstrated to ...[more]