Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC6058529 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yang Jincheng J Lv Qingzhi Q Wei Wei W Yang Zhengtao Z Dong Jiajun J Zhang Ruoshi R Kan Qiming Q He Zhonggui Z Xu Youjun Y
Drug delivery 20181101 1
The efficacy of traditional chemotherapy often suffers from rapid clearance and off-target toxicity. Drug delivery systems and controlled release are applied to improve the therapeutic efficiencies of small-molecule drugs. In this work, two novel oxidative/reductive (Ox/Re) -sensitive and one non-sensitive Paclitaxel (PTX) prodrugs were synthesized with a maleimide group, which rapidly conjugates with albumin in vivo. Albumin serves as a good vehicle to deliver more prodrug to tumors due to the ...[more]