Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC6058606 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tian Li L Qiao Yang Y Lee Patrick P Wang Lucas L Chang Ashley A Ravi Saisree S Rogers Thomas A TA Lu Linfeng L Singhana Burapol B Zhao Jun J Melancon Marites P MP
Drug delivery 20181101 1
Irreversible electroporation (IRE) is an emerging minimally invasive tumor ablation technique that delivers short pulses of strong electric fields and kills cancer cells by disrupting their cell membranes with the electric pulses. However, clinical studies report that more than 10% of local tumor recurrences occur at the original ablated site. NVP BEZ-235 (BEZ) is a dual PI3K/mTOR inhibitor that has substantial anticancer effects. However, the clinical trials of BEZ was not satisfactory because ...[more]