Ontology highlight
ABSTRACT:
SUBMITTER: Taraseviciute A
PROVIDER: S-EPMC6058704 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Taraseviciute Agne A Tkachev Victor V Ponce Rafael R Turtle Cameron J CJ Snyder Jessica M JM Liggitt H Denny HD Myerson David D Gonzalez-Cuyar Luis L Baldessari Audrey A English Chris C Yu Alison A Zheng Hengqi H Furlan Scott N SN Hunt Daniel J DJ Hoglund Virginia V Finney Olivia O Brakke Hannah H Blazar Bruce R BR Berger Carolina C Riddell Stanley R SR Gardner Rebecca R Kean Leslie S LS Jensen Michael C MC
Cancer discovery 20180321 6
Chimeric antigen receptor (CAR) T-cell immunotherapy has revolutionized the treatment of refractory leukemias and lymphomas, but is associated with significant toxicities, namely cytokine release syndrome (CRS) and neurotoxicity. A major barrier to developing therapeutics to prevent CAR T cell-mediated neurotoxicity is the lack of clinically relevant models. Accordingly, we developed a rhesus macaque (RM) model of neurotoxicity via adoptive transfer of autologous CD20-specific CAR T cells. Follo ...[more]