Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury.
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SUBMITTER: Song HF
PROVIDER: S-EPMC6059002 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury.
Song Hui-Fang HF He Sheng S Li Shu-Hong SH Yin Wen-Juan WJ Wu Jun J Guo Jian J Shao Zheng-Bo ZB Zhai Xiao-Yan XY Gong Hui H Lu Li L Wei Fang F Weisel Richard D RD Xie Jun J Li Ren-Ke RK
JACC. Basic to translational science 20171129 6
Reduced regenerative capacity of aged stem cells hampers the benefits of autologous cell therapy for cardiac regeneration. This study investigated whether neuron-derived neurotrophic factor (NDNF) could rejuvenate aged human bone marrow (hBM)- multipotent mesenchymal stromal cells (MSCs) and whether the rejuvenated hBM-MSCs could improve cardiac repair after ischemic injury. Over-expression of NDNF in old hBM-MSCs decreased cell senescence and apoptosis. Engraftment of NDNF over-expressing old h ...[more]
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