Dataset Information

A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

ABSTRACT:

Background

Blood-based biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are urgently needed. Current biomarkers lack high sensitivity and specificity for population screening. The gold-standard biomarker, CA 19-9, also fails to demonstrate the predictive value necessary for early detection.

Methods

To validate a functional genomics-based plasma migration signature biomarker panel, plasma tissue factor pathway inhibitor (TFPI), tenascin C (TNC-FN III-C), and CA 19-9 levels were measured by enzyme-linked immunosorbent assays in three early-stage PDAC plasma cohorts, including two independent blinded validation cohorts containing a total of 43 stage I, 163 stage II, 86 chronic pancreatitis, 31 acute biliary obstruction, and 108 controls. Logistic regression models developed classification rules combining TFPI and/or TNC-FN III-C with CA 19-9 for patient cases and control subjects, with or without adjustment for age and diabetes status. Model classification performance was evaluated and analyses repeated among subpopulations without diabetes and pancreatitis history. Two-sided P values were calculated using bootstrap method.

Results

The TFPI/TNC-FN III-C/CA 19-9 panel improved CA 19-9 performance in all early-stage cohorts, including discriminating stage IA/IB/IIA, stage IIB, and all early-stage cancer from healthy controls. Statistical significance was reached for a number of subcohorts, including for all early-stage cancer vs healthy controls (cohort 1 AUC?=?0.92, 95% CI?=?0.86 to 0.96, P ?=?.04; cohort 3 AUC?=?0.83, 95% CI?=?0.76 to 0.89, P ?=?.045). Among subcohorts without diabetes and pancreatitis history, the panel approaches potential clinical utility for early detection to discriminate early-stage PDAC from healthy controls including an area under the curve (AUC) of 0.87 (95% CI?=?0.77 to 0.95) for stage I/IIA, an AUC of 0.93 (95% CI?=?0.87 to 0.98) for stage IIB, and a statistically significant AUC of 0.89 (95% CI?=?0.82 to 0.95) for all early-stage cancer ( P ?=?.03).

Conclusions

TFPI/TNC-FN III-C migration signature adds statistically significantly to CA 19-9's predictive power to detect early-stage PDAC and may have clinical utility for early detection of surgically resectable PDAC, as well as for enhanced survival from this routinely lethal cancer.

SUBMITTER: Balasenthil S

PROVIDER: S-EPMC6059209 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

Balasenthil Seetharaman S Huang Ying Y Liu Suyu S Marsh Tracey T Chen Jinyun J Stass Sanford A SA KuKuruga Debra D Brand Randall R Chen Nanyue N Frazier Marsha L ML Jack Lee J J Srivastava Sudhir S Sen Subrata S McNeill Killary Ann A

Journal of the National Cancer Institute 20170801 8

<h4>Background</h4>Blood-based biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are urgently needed. Current biomarkers lack high sensitivity and specificity for population screening. The gold-standard biomarker, CA 19-9, also fails to demonstrate the predictive value necessary for early detection.<h4>Methods</h4>To validate a functional genomics-based plasma migration signature biomarker panel, plasma tissue factor pathway inhibitor (TFPI), tenascin C (TNC-FN III-C), an ...[more]

PMID: 28376184

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Dataset Information

A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

Background

Methods

Results

Conclusions

Publications

A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer.

Similar Datasets

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