Dataset Information

Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study.

ABSTRACT:

Objective

Patients with colorectal carcinoma (CRC) with pre-existing chronic liver disease (CLD) had a significantly higher 30-day mortality after CRC surgery compared with healthy controls. This study investigated the factors associated with postoperative complications and in-hospital mortality in patients with CRC with coexisting CLD (excluding cirrhosis) who underwent colorectal surgery.

Design

A retrospective, observational, population-based study.

Setting

Data were sourced from the National Inpatient Sample database, a part of the Healthcare Cost and Utilisation Project.

Participants

This study analysed 7463 inpatients with CRC who underwent colorectal surgery on admission between 2005 and 2014.

Primary and secondary outcome measures

The primary endpoint of this study was the prevalence of postoperative complications, and the secondary endpoint was in-hospital mortality.

Results

In the CLD group, 36.27% of patients had chronic hepatitis C, 28.36% had non-alcoholic fatty liver disease and 31.19% had other types of CLD. The median hospital stay was 7.0 (5.0-10.0) days in patients with no postoperative complications vs 17.0 (10.0-26.0) days, 8.0 (6.0-12.0) days, 8.0 (6.0-17.0) days, 9.0 (8.0-14.0) days and 10.5 (7.0-17.0) days for patients with postoperative infection, postoperative bleeding, cardiac arrest/heart failure, respiratory complications and digestive complications, respectively (all p<0.05). The presence of CLD was significantly associated with higher risk of postoperative bleeding (adjusted OR (aOR)=1.64, 95% CI 1.15 to 2.34, p=0.007). The presence of CLD (aOR=1.98, 95% CI 1.39 to 2.82, p<0.001) and length of hospital stay (aOR=1.06, 95% CI 1.04 to 1.08, p<0.001) were significantly associated with higher risk of in-hospital mortality. However, hyperlipidaemia was associated with a significantly lower risk of mortality (aOR=0.46, 95% CI 0.28 to 0.75, p=0.002).

Conclusions

Postoperative complications prolonged the length of hospital stay. The presence of CLD and hyperlipidaemia were important factors impacting postoperative complications and in-hospital mortality in patients with CRC with underlying CLD.

SUBMITTER: Lee KC

PROVIDER: S-EPMC6059287 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study.

Lee Ko-Chao KC Chung Kuan-Chih KC Chen Hong-Hwa HH Cheng Kung-Chuan KC Wu Kuen-Lin KL Lu Chien-Chang CC

BMJ open 20180717 7

<h4>Objective</h4>Patients with colorectal carcinoma (CRC) with pre-existing chronic liver disease (CLD) had a significantly higher 30-day mortality after CRC surgery compared with healthy controls. This study investigated the factors associated with postoperative complications and in-hospital mortality in patients with CRC with coexisting CLD (excluding cirrhosis) who underwent colorectal surgery.<h4>Design</h4>A retrospective, observational, population-based study.<h4>Setting</h4>Data were sou ...[more]

PMID: 30018094

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Dataset Information

Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study.

Objective

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study.

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