Dataset Information

Maternal lead exposure and premature rupture of membranes: a birth cohort study in China.

ABSTRACT:

Objectives

Maternal exposure to lead (Pb) has been suggested to correlate with adverse birth outcomes, but evidence supporting an association between Pb exposure and premature rupture of membranes (PROM) is limited. The aim of our study was to investigate whether maternal Pb exposure was associated with PROM and preterm PROM.

Design

Cross-sectional cohort study.

Study population

The present study involved 7290 pregnant women from the Healthy Baby Cohort in Wuhan, China, during 2012-2014.

Main outcome measures

PROM was defined as spontaneous rupture of amniotic membranes before the onset of labour and was determined with a pH ?6.5 for vaginal fluid. Maternal urinary Pb level was adjusted by creatinine concentration, and its relationship with PROM was analysed by logistic regression.

Results

The IQR of maternal urinary Pb concentrations of the study population was 2.30-5.64?µg/g creatinine with a median of 3.44?µg/g creatinine. Increased risk of PROM was significantly associated with elevated levels of Pb in maternal urine (adjusted OR 1.23, 95% CI 1.0 to 1.47 for the medium tertile; adjusted OR 1.51, 95%?CI 1.27 to 1.80 for the highest tertile). The risk of preterm PROM associated with Pb levels was significantly higher when compared with the lowest tertile (adjusted OR 1.24, 95%?CI 0.80 to 1.92 for the medium tertile; adjusted OR 1.73, 95%?CI 1.15 to 2.60 for the highest tertile). In addition, the relationship between Pb and PROM was more pronounced among primiparous women than multiparous women (p for interaction <0.01).

Conclusions

Our study found that higher levels of maternal Pb exposure was associated with increased risk of PROM, indicating that exposure to Pb during pregnancy may be an important risk factor for PROM.

SUBMITTER: Huang S

PROVIDER: S-EPMC6059302 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Maternal lead exposure and premature rupture of membranes: a birth cohort study in China.

Huang Sha S Xia Wei W Sheng Xia X Qiu Lin L Zhang Bin B Chen Tian T Xu Shunqing S Li Yuanyuan Y

BMJ open 20180723 7

<h4>Objectives</h4>Maternal exposure to lead (Pb) has been suggested to correlate with adverse birth outcomes, but evidence supporting an association between Pb exposure and premature rupture of membranes (PROM) is limited. The aim of our study was to investigate whether maternal Pb exposure was associated with PROM and preterm PROM.<h4>Design</h4>Cross-sectional cohort study.<h4>Study population</h4>The present study involved 7290 pregnant women from the Healthy Baby Cohort in Wuhan, China, dur ...[more]

PMID: 30037873

Similar Datasets

Project description:BACKGROUND:The associations between maternal exposure to ambient PM2.5 during pregnancy and the risk of premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM) are controversial. And no relevant study has been conducted in Asia. This study aimed to determine the association between maternal exposure to ambient PM2.5 during pregnancy and the risk of (P)PROM. METHODS:A cohort study including all singleton births in a hospital located in Central China from January 2015 through December 2017 was conducted. Multivariable logistic regression models, stratified analysis, generalized additive model, and two-piece-wise linear regression were conducted to evaluate how exposure to ambient PM2.5 during pregnancy is associated with the risks of PROM and PPROM. RESULTS:A total of 4364 participants were included in the final analysis, where 11.71 and 2.34% of births were complicated by PROM and PPROM, respectively. The level of PM2.5 exhibited a degree of seasonal variation, and its median concentrations were 63.7, 59.3, 55.8, and 61.8??g/m3 for the first trimester, second trimester, third trimester, and the whole duration of pregnancy, respectively. After adjustment for potential confounders, PROM was positively associated with PM2.5 exposure (per 10??g/m3) [Odds Ratio (OR)?=?1.14, 95% Confidence Interval (CI), 1.02-1.26 for the first trimester; OR?=?1.09, 95% CI, 1.00-1.18 for the second trimester; OR?=?1.13, 95% CI, 1.03-1.24 for the third trimester; OR?=?1.35, 95% CI, 1.12-1.63 for the whole pregnancy]. PPROM had positive relationship with PM2.5 exposure (per 10??g/m3) (OR?=?1.17, 95% CI, 0.94-1.45 for first trimester; OR?=?1.11, 95% CI, 0.92-1.33 for second trimester; OR?=?1.19, 95% CI, 0.99-1.44 for third trimester; OR?=?1.53, 95% CI, 1.03-2.27 for the whole pregnancy) Positive trends between the acute exposure window (mean concentration of PM2.5 in the last week and day of pregnancy) and risks of PROM and PPROM were also observed. CONCLUSIONS:Exposure to ambient PM2.5 during pregnancy was associated with the risk of PROM and PPROM.

Dataset Information

Maternal lead exposure and premature rupture of membranes: a birth cohort study in China.

Objectives

Design

Study population

Main outcome measures

Results

Conclusions

Publications

Maternal lead exposure and premature rupture of membranes: a birth cohort study in China.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets