GPCR-SAS: A web application for statistical analyses on G protein-coupled receptors sequences.

ABSTRACT: G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. They mediate signal transduction across cell membranes and are important targets for the pharmaceutical industry. The G Protein-Coupled Receptors-Sequence Analysis and Statistics (GPCR-SAS) web application provides a set of tools to perform comparative analysis of sequence positions between receptors, based on a curated structural-informed multiple sequence alignment. The analysis tools include: (i) percentage of occurrence of an amino acid or motif and entropy at a position or range of positions, (ii) covariance of two positions, (iii) correlation between two amino acids in two positions (or two sequence motifs in two ranges of positions), and (iv) snake-plot representation for a specific receptor or f

SUBMITTER: Gomez Tamayo JC 

PROVIDER: S-EPMC6059404 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature