Ontology highlight
ABSTRACT:
SUBMITTER: Hao Y
PROVIDER: S-EPMC6059440 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hao Yue Y Purtha Whitney W Cortesio Christa C Rui Huan H Gu Yan Y Chen Hao H Sickmier E Allen EA Manzanillo Paolo P Huang Xin X
PloS one 20180725 7
Cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases. It is the only known aminopeptidase in the family and is reported to be involved in cancer and other major diseases. Like many other proteases, it is synthesized as an inactive proenzyme. Although the crystal structure of mature porcine cathepsin H revealed the binding of the mini-chain and provided structural basis for the aminopeptidase activity, detailed structural and functional information on the inhibition a ...[more]