Ontology highlight
ABSTRACT:
SUBMITTER: Scarpa JR
PROVIDER: S-EPMC6059761 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Scarpa Joseph R JR Jiang Peng P Gao Vance D VD Fitzpatrick Karrie K Millstein Joshua J Olker Christopher C Gotter Anthony A Winrow Christopher J CJ Renger John J JJ Kasarskis Andrew A Turek Fred W FW Vitaterna Martha H MH
Science advances 20180725 7
To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J × 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions. We identified converging molecular bases for sleep and affective phenotypes at both the single-gene and gene-network levels. Using publicly available transcriptomic datasets collected from sleep-deprived mice and patients with major depressive diso ...[more]