Unknown

Dataset Information

0

Application of Genome Editing Techniques in Immunology.


ABSTRACT: The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such receptors, there is also a need for disruption of certain genes in the immune cells to achieve more potent disease-targeted actions, to produce universal chimeric antigen receptor-based therapies or to study the signaling pathways in detail. In this review, we present novel genetic engineering methods, mainly TALEN and CRISPR/Cas9 systems, that can be used for such purposes. These unique techniques may contribute to creating more successful immune therapies against cancer or prospectively other diseases as well.

SUBMITTER: Zych AO 

PROVIDER: S-EPMC6061149 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Application of Genome Editing Techniques in Immunology.

Zych Agata O AO   Bajor Malgorzata M   Zagozdzon Radoslaw R  

Archivum immunologiae et therapiae experimentalis 20180117 4


The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such receptors, there is also a need for disruption of certain genes in the immune cells to achieve more potent disease-targeted  ...[more]

Similar Datasets

| S-EPMC5042211 | biostudies-literature
| S-EPMC5999541 | biostudies-literature
| S-EPMC9974761 | biostudies-literature
| S-EPMC8309286 | biostudies-literature
| S-EPMC4595993 | biostudies-other
| S-EPMC7694359 | biostudies-literature
| S-EPMC9140762 | biostudies-literature
| S-EPMC8525356 | biostudies-literature
| S-EPMC7915733 | biostudies-literature
| S-EPMC9147844 | biostudies-literature