Ontology highlight
ABSTRACT:
SUBMITTER: Reddy IA
PROVIDER: S-EPMC6061973 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
PLoS biology 20180726 7
The gut-to-brain axis exhibits significant control over motivated behavior. However, mechanisms supporting this communication are poorly understood. We reveal that a gut-based bariatric surgery chronically elevates systemic bile acids and attenuates cocaine-induced elevations in accumbal dopamine. Notably, this surgery reduces reward-related behavior and psychomotor sensitization to cocaine. Utilizing a knockout mouse model, we have determined that a main mediator of these post-operative effects ...[more]