Ontology highlight
ABSTRACT:
SUBMITTER: Glauzy S
PROVIDER: S-EPMC6062007 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Glauzy Salomé S Sng Joel J Bannock Jason M JM Gottenberg Jacques-Eric JE Korganow Anne-Sophie AS Cacoub Patrice P Saadoun David D Meffre Eric E
Arthritis & rheumatology (Hoboken, N.J.) 20171012 11
<h4>Objective</h4>Central and peripheral B cell tolerance checkpoints are defective in many patients with autoimmune diseases, but the functionality of each discrete checkpoint has not been assessed in patients with Sjögren's syndrome (SS). We undertook this study to assess this functionality in SS patients.<h4>Methods</h4>Using a polymerase chain reaction-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by single B cells, we tested the reactivity of ...[more]