Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum.

ABSTRACT: Derivatives from the Cannabis plant are the most commonly abused illegal substances in the world. The main psychoactive component found in the plant, Δ-9-tetrahydrocannabinol (THC), exerts its effects through the endocannabinoid system. Manipulations of this system affect some types of learning that seem to be dependent on dorsal striatum synaptic plasticity. Dendritic spines exhibit important synaptic functional attributes and a potential for plasticity, which is thought to mediate long-lasting changes in behaviour. To study the possible structural plasticity changes that prolonged THC administration might exert in the dorsal striatum, adult, male C57BL6/J mice were intraperitoneally injected with THC (10mg/kg) or vehicle for 15 days followed by a 7-day drug-free period. Using single cell

SUBMITTER: Fernandez-Cabrera MR 

PROVIDER: S-EPMC6062058 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature