Ontology highlight
ABSTRACT:
SUBMITTER: Jora M
PROVIDER: S-EPMC6062210 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jora Manasses M Burns Andrew P AP Ross Robert L RL Lobue Peter A PA Zhao Ruoxia R Palumbo Cody M CM Beal Peter A PA Addepalli Balasubrahmanyam B Limbach Patrick A PA
Journal of the American Society for Mass Spectrometry 20180612 8
The analytical identification of positional isomers (e.g., 3-, N<sup>4</sup>-, 5-methylcytidine) within the > 160 different post-transcriptional modifications found in RNA can be challenging. Conventional liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) approaches rely on chromatographic separation for accurate identification because the collision-induced dissociation (CID) mass spectra of these isomers nearly exclusively yield identical nucleobase ions (BH<sub>2</sub><sup> ...[more]