Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System.
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ABSTRACT:
SUBMITTER: Srinivas N
PROVIDER: S-EPMC6062484 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System.
Srinivas Nithya N Maffuid Kaitlyn K Kashuba Angela D M ADM
Clinical pharmacokinetics 20180901 9
Despite contributing significantly to the burden of global disease, the translation of new treatment strategies for diseases of the central nervous system (CNS) from animals to humans remains challenging, with a high attrition rate in the development of CNS drugs. The failure of clinical trials for CNS therapies can be partially explained by factors related to pharmacokinetics/pharmacodynamics (PK/PD), such as lack of efficacy or improper selection of the initial dosage. A focused assessment is ...[more]
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