Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto I
PROVIDER: S-EPMC6062494 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Yamamoto Itaru I Azuma Yumiko Y Kushimura Yukie Y Yoshida Hideki H Mizuta Ikuko I Mizuno Toshiki T Ueyama Morio M Nagai Yoshitaka Y Tokuda Takahiko T Yamaguchi Masamitsu M
Scientific reports 20180726 1
Fused in sarcoma (FUS) was identified as a component of typical inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear and cytoplasmic inclusions with wild-type FUS exist, while cytoplasmic inclusions with a mutant-form of FUS occur in many ALS cases. These observations imply that FUS plays a role across these two diseases. In this study, we examined the effect of several proteins including molecular chaperons on the aberrant eye mor ...[more]