Ontology highlight
ABSTRACT:
SUBMITTER: Yordanova Y
PROVIDER: S-EPMC6062538 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Yordanova Yordanka Y Vanderlinden Willem W Stoll Raphael R Rüdiger Daniel D Tosstorff Andreas A Zaremba Wolfgang W Winter Gerhard G Zahler Stefan S Friess Wolfgang W
Scientific reports 20180726 1
A synthetic derivative, GnRH [6-D-Phe], stable against enzymatic degradation, self-assembles and forms nanostructures and fibrils upon a pH shift in the presence of different concentrations of Zn<sup>2+</sup> in vitro. Attenuated Total Reflection Fourier Transform Infrared spectroscopy (ATR-FTIR) revealed the existence of higher order assembly of Zn<sup>2+</sup>: GnRH [6-D-Phe]. Nuclear Magnetic Resonance spectroscopy (NMR) indicated a weak interaction between Zn<sup>2+</sup> and GnRH [6-D-Phe]. ...[more]