Ontology highlight
ABSTRACT:
SUBMITTER: Clement CC
PROVIDER: S-EPMC6062610 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Clement Cristina C CC Wang Wei W Dzieciatkowska Monika M Cortese Marco M Hansen Kirk C KC Becerra Aniuska A Thangaswamy Sangeetha S Nizamutdinova Irina I Moon Jee-Young JY Stern Lawrence J LJ Gashev Anatoliy A AA Zawieja David D Santambrogio Laura L
Scientific reports 20180726 1
Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in lymphatic fluid has not been reported. Here we quantified the efficiency of nodal clearance of the composite proteomic load using label-free and isotope-labeling proteomic analysis of pre-nodal and post ...[more]