Ontology highlight
ABSTRACT:
SUBMITTER: Diwan GD
PROVIDER: S-EPMC6063277 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Diwan Gaurav D GD Agashe Deepa D
Molecular biology and evolution 20180801 8
Along with tRNAs, enzymes that modify anticodon bases are a key aspect of translation across the tree of life. tRNA modifications extend wobble pairing, allowing specific ("target") tRNAs to recognize multiple codons and cover for other ("nontarget") tRNAs, often improving translation efficiency and accuracy. However, the detailed evolutionary history and impact of tRNA modifying enzymes has not been analyzed. Using ancestral reconstruction of five tRNA modifications across 1093 bacteria, we sho ...[more]