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Lipidome Evolution in Mammalian Tissues.

ABSTRACT: Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.

SUBMITTER: Khrameeva E

PROVIDER: S-EPMC6063302 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Lipidome Evolution in Mammalian Tissues.

Khrameeva Ekaterina E Kurochkin Ilia I Bozek Katarzyna K Giavalisco Patrick P Khaitovich Philipp P

Molecular biology and evolution 20180801 8

Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions s ...[more]

PMID: 29762743

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