Ontology highlight
ABSTRACT:
SUBMITTER: Millership SJ
PROVIDER: S-EPMC6063487 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Millership Steven J SJ Da Silva Xavier Gabriela G Choudhury Agharul I AI Bertazzo Sergio S Chabosseau Pauline P Pedroni Silvia Ma SM Irvine Elaine E EE Montoya Alex A Faull Peter P Taylor William R WR Kerr-Conte Julie J Pattou Francois F Ferrer Jorge J Christian Mark M John Rosalind M RM Latreille Mathieu M Liu Ming M Rutter Guy A GA Scott James J Withers Dominic J DJ
The Journal of clinical investigation 20180709 8
Neuronatin (Nnat) is an imprinted gene implicated in human obesity and widely expressed in neuroendocrine and metabolic tissues in a hormone- and nutrient-sensitive manner. However, its molecular and cellular functions and precise role in organismal physiology remain only partly defined. Here we demonstrate that mice lacking Nnat globally or specifically in β cells display impaired glucose-stimulated insulin secretion leading to defective glucose handling under conditions of nutrient excess. In ...[more]