Ontology highlight
ABSTRACT:
SUBMITTER: Hao Y
PROVIDER: S-EPMC6063738 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Hao Yun Y Quinnies Kayla K Realubit Ronald R Karan Charles C Tatonetti Nicholas P NP
CPT: pharmacometrics & systems pharmacology 20180619 7
Understanding the downstream consequences of pharmacologically targeted proteins is essential to drug design. Current approaches investigate molecular effects under tissue-naïve assumptions. Many target proteins, however, have tissue-specific expression. A systematic study connecting drugs to target pathways in in vivo human tissues is needed. We introduced a data-driven method that integrates drug-target relationships with gene expression, protein-protein interaction, and pathway annotation dat ...[more]