Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6063898 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180727 1
Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade, but its treatment benefits are limited by acquired resistance, a process that remains incompletely understood. Here we report that an enhancer, located between the promoters of marker of proliferation Ki67 (MKI67) and O6-methylguanine-DNA-methyltransferase (MGMT) genes, is activated in TMZ-resistant patient-derived xenograft (PDX) lines and recurrent tumor samples. Activation of the enhancer correlates with in ...[more]