Ontology highlight
ABSTRACT:
SUBMITTER: Pierson HE
PROVIDER: S-EPMC6063947 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Pierson Hannah E HE Kaler Mandeep M O'Grady Christopher C Uhlemann Eva-Maria E EE Dmitriev Oleg Y OY
Scientific reports 20180727 1
ATP synthase is powered by the flow of protons through the molecular turbine composed of two α-helical integral membrane proteins, subunit a, which makes a stator, and a cylindrical rotor assembly made of multiple copies of subunit c. Transient protonation of a universally conserved carboxylate on subunit c (D61 in E. coli) gated by the electrostatic interaction with arginine on subunit a (R210 in E. coli) is believed to be a crucial step in proton transfer across the membrane. We used a fusion ...[more]