Dataset Information

Family History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort.

ABSTRACT: PURPOSE:To determine the relationship between positive family history (FH) and primary open-angle glaucoma (POAG) diagnosis and clinical presentation in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) cohort. METHODS:FH of POAG in first-degree relatives was assessed in 2365 subjects in the POAAGG cohort. A standardized interview was used to assess FH of glaucoma, demographic characteristics, lifestyle choices, and medical and ocular comorbidities. RESULTS:Positive FH was associated with increased risk of POAG (age-adjusted odds ratio and 95% confidence interval 3.4 [2.8, 4.1]). In age-adjusted analysis among POAG cases, positive FH was associated with younger age (P < .001), female sex (P < .001), hypertension (P = .006), use of hypertension medication (P = .03), and prior glaucoma surgery (P = .02). Cases with positive FH also had thicker retinal nerve fiber layers (P = .03). CONCLUSIONS:The risk conferred by positive FH suggests strong genetic underpinnings for some patients with this disease, which will be investigated by genome-wide association studies and whole exome sequencing. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.

SUBMITTER: O'Brien JM

PROVIDER: S-EPMC6064667 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Family History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort.

O'Brien Joan M JM Salowe Rebecca J RJ Fertig Raymond R Salinas Julia J Pistilli Maxwell M Sankar Prithvi S PS Miller-Ellis Eydie E Lehman Amanda A Murphy Windell H A WHA Homsher Melissa M Gordon Katelyn K Ying Gui-Shuang GS

American journal of ophthalmology 20180317

<h4>Purpose</h4>To determine the relationship between positive family history (FH) and primary open-angle glaucoma (POAG) diagnosis and clinical presentation in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) cohort.<h4>Methods</h4>FH of POAG in first-degree relatives was assessed in 2365 subjects in the POAAGG cohort. A standardized interview was used to assess FH of glaucoma, demographic characteristics, lifestyle choices, and medical and ocular comorbidities.<h4>Results</h4 ...[more]

PMID: 29555482

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Project description:PurposeTo investigate the prevalence and factors associated with optic disc tilt in the eyes of Black Americans with glaucoma.DesignCross-sectional.ParticipantsSubjects with glaucoma participating in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.MethodsStereo pairs of optic disc images were assessed independently by POAAGG-certified nonphysician graders for quantitative features including maximum and minimum linear disc diameters, and qualitative features including gradeability of images, shape of the cup, rim plane position, β-peripapillary atrophy, sloping region adjacent to the outer disc margin, and rim pallor. Discrepancies were adjudicated by an ophthalmologist. Descriptive statistics and P values were generated for associations of tilt with demographic and ocular characteristics. Stepwise multivariable analysis was performed with logistic regression using Generalized Estimating Equations (GEEs) to account for inter-eye correlation within subjects.Main outcome measuresTilt Ovality Index (TOI) of >1.30 and Stereoscopically Identified optic disc Tilt (SIT).ResultsAmong 1251 subjects with data on both eyes, 104 (8.3%) had TOI. Subjects with TOI were less likely to be male (adjusted odds ratio [aOR], 0.46, 95% confidence interval [CI], 0.29-0.74, P < 0.001). Eyes with TOI were less likely to have large cup disc ratios (aOR, 0.18, 95% CI, 0.06-0.53, P < 0.001) and less likely to have cylinder-shaped cups compared with conical-shaped cups (aOR, 0.31, 95% CI, 0.19-0.49, P < 0.001). Among 1007 subjects with data on both eyes, 254 (25.2%) had SIT. Subjects with SIT were younger (aOR, 0.95, 95% CI, 0.93-0.96, P < 0.001), and eyes with SIT were more likely to have oval-shaped discs compared with round discs (aOR, 1.82, 95% CI, 1.32-2.52, P < 0.001), more likely to have a sloping region adjacent to the outer disc margin instead of being flat (aOR, 3.26, 95% CI, 2.32-4.59, P < 0.001), and less likely to have cylinder-shaped cups compared with conical-shaped cups (aOR, 0.59, 95% CI, 0.41-0.85, P < 0.001). Both TOI and SIT were not associated with myopia.ConclusionsThere are substantial numbers of tilted optic discs in glaucoma patients with African ancestry. They occur more frequently in female subjects and younger subjects and are associated with several ocular features but not with myopia.

Dataset Information

Family History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort.

Publications

Family History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort.

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