Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC6064999 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wu Hao H Chen Wei W Zhao Fei F Zhou Qingyi Q Reinach Peter S PS Deng Lili L Ma Li L Luo Shumeng S Srinivasalu Nethrajeith N Pan Miaozhen M Hu Yang Y Pei Xiaomeng X Sun Jing J Ren Ran R Xiong Yinghui Y Zhou Zhonglou Z Zhang Sen S Tian Geng G Fang Jianhuo J Zhang Lina L Lang Jidong J Wu Deng D Zeng Changqing C Qu Jia J Zhou Xiangtian X
Proceedings of the National Academy of Sciences of the United States of America 20180709 30
Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate extension of the ocular axis and concomitant declines in scleral strength and thickness caused by extracellular matrix (ECM) remodeling. However, the identities of the initiators and signaling pathways that induce scleral ECM remodeling in myopia are unknown. Here, we used single-cell RNA-sequencing to identify pathways activated in the sclera during myopia development. We found that the hypoxia-signaling, ...[more]