Ontology highlight
ABSTRACT:
SUBMITTER: Leloup N
PROVIDER: S-EPMC6065357 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Leloup Nadia N Chataigner Lucas M P LMP Janssen Bert J C BJC
Nature communications 20180730 1
Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity, induces apoptosis and is associated with mental disorders. The detailed structure of SorCS2 and its extracellular specificity are unresolved. Here we report crystal structures of the SorCS2-NGF complex and unliganded SorCS2 ectodomain, revealing cross-braced SorCS2 homodimers with two NGF dimers bound in a 2:4 stoichiometry. Five out of six SorCS2 domains directly contribute to dimer formation and a C-terminal ...[more]