Dataset Information

Polymorphism of IFN-? +874T/A associated with production of IFN-? affects human papillomavirus susceptibility in rural women from Luohe, Henan, China.

ABSTRACT: Purpose:In this paper, the association between polymorphisms of IFN-? +874T/A (rs2430561), IFN-?R1 -56 T/C (rs2234711), IFN-?R1 +95 C/T (rs7749390), and IFN-?R1 -611A/G (rs 1327474) and human papillomavirus (HPV) susceptibility was investigated in rural women from Luohe, Henan, China. Patients and methods:A total of 520 rural women were enrolled from Luohe, including 260 with HPV infection and mild dysplasia or less and 260 without HPV infection. Single-nucleotide polymorphisms (SNPs) of IFN-? +874T/A, IFN-?R1 -56 T/C, IFN-?R1 +95 C/T and IFN-?R1 -611A/G were genotyped using TaqMan Pre-Designed SNP Genotyping Assays. Serum IFN-? levels were measured using Human IFN-? Quantikine ELISA Kit. Multivariate logistic regression analysis was performed to identify the SNPs associated with HPV susceptibility. Serum IFN-? levels were compared between different genotypes. Results:The polymorphism of IFN-? +874T/A was associated with HPV susceptibility and +874A carriers had an increased risk. Moreover, the odds ratio was higher in +874 AA carriers than in +874 AT carriers (1.672 vs 2.874). Serum IFN-? levels were highest in IFN-? +874 TT carriers, intermediate in AT carriers, and lowest in AA carriers (2.86±1.14 vs 1.57±0.79 vs 0.41±0.22 pg/mL, all P<0.05). Conclusion:The polymorphism of IFN-? +874T/A was associated with HPV susceptibility in rural women from Luohe, Henan, China, and +874A carriers had an increased risk. The possible mechanism was that +874A carriers had a low production of IFN-?.

SUBMITTER: Zhang QW

PROVIDER: S-EPMC6065563 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Polymorphism of IFN-γ +874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China.

Zhang Qing-Wei QW Song Jia-Yu JY Yu Jiang-Hua JH Sun Ming-Zhen MZ Tang Si-Yuan SY Yang Shao-Zhe SZ Cao Lei-Jia LJ Wang Hui-Fen HF Cui Li-Na LN Fu Xiu-Hong XH

OncoTargets and therapy 20180725

<h4>Purpose</h4>In this paper, the association between polymorphisms of IFN-γ +874T/A (rs2430561), IFN-γR1 -56 T/C (rs2234711), IFN-γR1 +95 C/T (rs7749390), and IFN-γR1 -611A/G (rs 1327474) and human papillomavirus (HPV) susceptibility was investigated in rural women from Luohe, Henan, China.<h4>Patients and methods</h4>A total of 520 rural women were enrolled from Luohe, including 260 with HPV infection and mild dysplasia or less and 260 without HPV infection. Single-nucleotide polymorphisms (S ...[more]

PMID: 30100739

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Project description:BackgroundCytochrome P450 (CYPs) are heme proteins involved in the metabolism of a variety of endogenous and exogenous substances and play an important role in the carcinogenesis mechanisms of environmental and hereditary factors. The objective of this study was to investigate how polymorphisms of CYPs correlate with lung cancer (LC) susceptibility.MethodsSix single nucleotide polymorphisms (SNPs) were genotyped in this study. The chi-square test and unconditional logistic regression model were used to evaluate the correlation between SNPs and LC susceptibility. The expressions and survival data of genes in patients with LC were mined using Oncomine and Kaplan-Meier Plotter database.ResultsFour SNPs were found to be significantly associated with the risk of LC development (P < 0.05). The most significant correlation was that the A allele and AA genotype of CYP2D6 rs1065852 were associated with increased risk of LC development (adjusted odds ratio [OR] = 1.35, 95% confidence interval [95%CI] = 1.13-1.60, P = 9.04e-4; OR = 1.83, 95%CI = 1.29-2.59, P = 0.001 respectively). Similar association of this variant was also found in the subgroups of male patients, cases in III-IV stages, positive lymph node, squamous cell carcinomas and adenocarcinomas. Whereas rs1065852 was considered as protective factor in females (adjusted OR = 0.33, 95% CI = 0.16-0.70, P = 0.004). In stratified analyses, the association of CYP24A1 rs2762934, CYP24A1 rs6068816, CYP20A1 rs2043449 polymorphism with LC risk appeared stronger in some subgroups. CYP2D6, CYP24A1 and CYP20A1 are overexpressed in some pathological types of LC (P < 0.05), and high levels of CYP2D6 and CYP20A1 indicate poor and good prognosis of LC, respectively.ConclusionThis study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.

Dataset Information

Polymorphism of IFN-? +874T/A associated with production of IFN-? affects human papillomavirus susceptibility in rural women from Luohe, Henan, China.

Publications

Polymorphism of IFN-γ +874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China.

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