Ontology highlight
ABSTRACT:
SUBMITTER: Shafraz O
PROVIDER: S-EPMC6066328 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Shafraz Omer O Rübsam Matthias M Stahley Sara N SN Caldara Amber L AL Kowalczyk Andrew P AP Niessen Carien M CM Sivasankar Sanjeevi S
eLife 20180712
Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both <i>trans</i> (between opposing cells) and <i>cis</i> (on the same cell surface) conformations, facilitates desmosome assembly via an unknown mechanism. Here we use structure-function analysis to resolve the mechanistic roles of Ecad in desmosome formation. Using AFM force measurements, we de ...[more]