Ontology highlight
ABSTRACT:
SUBMITTER: Kato J
PROVIDER: S-EPMC6066329 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
eLife 20180717
Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a <i>Salmonella</i> Typhimurium T3SS that assembly of the needle filament of this structure requires OrgC, a protein encoded within the T3SS gene cluster. Absence of OrgC results in significantly reduced number of needle substructures but does not affect needle length. We show that OrgC is secreted by the T3SS and that ...[more]