Dataset Information

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women.

ABSTRACT:

Background

Limited evidence links air pollution exposure to chronic cough and sputum production. Few reports have investigated the association between long-term exposure to air pollution and classically defined chronic bronchitis.

Objectives

Our objective was to estimate the association between long-term exposure to particulate matter (diameter <10??m, PM₁₀; <2.5?m, PM_2.5), nitrogen dioxide (NO₂), and both incident and prevalent chronic bronchitis.

Methods

We estimated annual average PM_2.5, PM₁₀, and NO₂ concentrations using a national land-use regression model with spatial smoothing at home addresses of participants in a prospective nationwide U.S. cohort study of sisters of women with breast cancer. Incident chronic bronchitis and prevalent chronic bronchitis, cough and phlegm, were assessed by questionnaires.

Results

Among 47,357 individuals with complete data, 1,383 had prevalent chronic bronchitis at baseline, and 647 incident cases occurred over 5.7-y average follow-up. No associations with incident chronic bronchitis were observed. Prevalent chronic bronchitis was associated with PM₁₀ [adjusted odds ratio (aOR) per interquartile range (IQR) difference (5.8^??g/m³)=1.07; 95% confidence interval (CI): 1.01, 1.13]. In never-smokers, PM_2.5 was associated with prevalent chronic bronchitis (aOR=1.18 per IQR difference; 95% CI: 1.04, 1.34), and _NO₂ was associated with prevalent chronic bronchitis (aOR=1.10; 95%?CI=1.01,?1.20), cough (aOR=1.10; 95% CI: 1.05, 1.16), and phlegm (aOR=1.07; 95% CI: 1.01, 1.14); interaction p-values (nonsmokers vs. smokers) <0.05.

Conclusions

PM₁₀ exposure was related to chronic bronchitis prevalence. Among never-smokers, PM_2.5 and NO₂ exposure was associated with chronic bronchitis and component symptoms. Results may have policy ramifications for PM₁₀ regulation by providing evidence for respiratory health effects related to long-term PM₁₀ exposure. https://doi.org/10.1289/EHP2199.

SUBMITTER: Hooper LG

PROVIDER: S-EPMC6066337 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women.

Hooper Laura G LG Young Michael T MT Keller Joshua P JP Szpiro Adam A AA O'Brien Katie M KM Sandler Dale P DP Vedal Sverre S Kaufman Joel D JD London Stephanie J SJ

Environmental health perspectives 20180206 2

<h4>Background</h4>Limited evidence links air pollution exposure to chronic cough and sputum production. Few reports have investigated the association between long-term exposure to air pollution and classically defined chronic bronchitis.<h4>Objectives</h4>Our objective was to estimate the association between long-term exposure to particulate matter (diameter <10 μm, PM<sub>10</sub>; <2.5μm, PM<sub>2.5</sub>), nitrogen dioxide (NO<sub>2</sub>), and both incident and prevalent chronic bronchitis. ...[more]

PMID: 29410384

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Dataset Information

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women.

Background

Objectives

Methods

Results

Conclusions

Publications

Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women.

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