High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Marquis M
PROVIDER: S-EPMC6066481 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.
Marquis Miriam M Beaubois Cyrielle C Lavallée Vincent-Philippe VP Abrahamowicz Michal M Danieli Coraline C Lemieux Sébastien S Ahmad Imran I Wei Andrew A Ting Stephen B SB Fleming Shaun S Schwarer Anthony A Grimwade David D Grey William W Hills Robert K RK Vyas Paresh P Russell Nigel N Sauvageau Guy G Hébert Josée J
Blood cancer journal 20180719 8
In acute myeloid leukemia (AML), risk stratification based on cytogenetics and mutation profiling is essential but remains insufficient to select the optimal therapy. Accurate biomarkers are needed to improve prognostic assessment. We analyzed RNA sequencing and survival data of 430 AML patients and identified HMGA2 as a novel prognostic marker. We validated a quantitative PCR test to study the association of HMGA2 expression with clinical outcomes in 358 AML samples. In this training cohort, HM ...[more]
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