Ontology highlight
ABSTRACT:
SUBMITTER: Marquis M
PROVIDER: S-EPMC6066481 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Blood cancer journal 20180719 8
In acute myeloid leukemia (AML), risk stratification based on cytogenetics and mutation profiling is essential but remains insufficient to select the optimal therapy. Accurate biomarkers are needed to improve prognostic assessment. We analyzed RNA sequencing and survival data of 430 AML patients and identified HMGA2 as a novel prognostic marker. We validated a quantitative PCR test to study the association of HMGA2 expression with clinical outcomes in 358 AML samples. In this training cohort, HM ...[more]