Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.
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ABSTRACT:
SUBMITTER: Furusawa Y
PROVIDER: S-EPMC6066526 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.
Furusawa Yuri Y Yamada Shinya S Kawaoka Yoshihiro Y
Frontiers in microbiology 20180724
Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, ...[more]
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